1-Aminocyclopentanemethanol → 5-Cyclopropyl-6-(cyclopropylmethoxy)-N-(1-(hydroxymethyl)cyclopentyl)picolinamide
반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C:19]1([CH2:24][OH:25])[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:18][C:19]3([CH2:24][OH:25])[CH2:23][CH2:22][CH2:21][CH2:20]3)=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1참가 물질
3
실험 절차
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and 1-amino-cyclopentanemethanol (CAN 10316-79-7) as starting materials, LC-MS (UV peak area/ESI) 100%, 331.2014 (M+H)+.
출처 및 근거
- ORD 기록
- ord-48c3998dab4c4967a0c67c488a131d16
- 출처 데이터셋
- uspto-grants-2016_03