6-(Cyclopropylmethoxy)-5-(6-oxa-1-azaspiro[3.3]heptan-1-yl)picolinic acid → 6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide

HRID 927678노트

반응식

HRID 927678 반응식
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12](O)=[O:13])[CH:9]=[CH:8][C:7]=2[N:15]2[C:18]3([CH2:21][O:20][CH2:19]3)[CH2:17][CH2:16]2)[CH2:3][CH2:2]1.C1(N(C2N=C(C)ON=2)C)CC1.[CH:33]1([CH2:36][C@H:37]([NH2:44])[C:38]2[N:42]=[C:41]([CH3:43])[O:40][N:39]=2)[CH2:35]C1>>[CH:36]1([CH:37]([NH:44][C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[C:18]4([CH2:19][O:20][CH2:21]4)[CH2:17][CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)[N:11]=2)=[O:13])[C:38]2[N:42]=[C:41]([CH3:43])[O:40][N:39]=2)[CH2:33][CH2:35]1

참가 물질

4

반응물 3

HCID 710877046-(Cyclopropylmethoxy)-5-(6-oxa-1-azaspiro[3.3]heptan-1-yl)picolinic acidHCID 86674748(S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamineHCID 86674778Cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine

생성물 1

HCID 711056656-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-(cyclopropylmethoxy)-5-(6-oxa-1-azaspiro[3.3]heptan-1-yl)picolinic acid (Example 234 b) and cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine (which can e.g. be prepared in a similar manner than (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e) as starting materials. MS (EI): m/e=426.0 [M+H]+.

출처 및 근거

ORD 기록
ord-063b0d6f75ca488ca4d494088d666bec
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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