Ethyl 2-amino-2-ethylbutanoate hydrochloride → 2-[(5-Bromo-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester

HRID 927707

반응식

HRID 927707 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([OH:15])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.Cl.[NH2:17][C:18]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH2:22]([O:21][C:19](=[O:20])[C:18]([NH:17][C:13]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:11][CH2:12]2)[N:6]=1)=[O:15])([CH2:26][CH3:27])[CH2:24][CH3:25])[CH3:23]

참가 물질

3

반응물 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 710875435-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 710872802-[(5-Bromo-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-bromo-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid (Example 9 d) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=415.0 [M+H]+.

출처 및 근거

ORD 기록
ord-f8fe5b9748eb425cb9f668745c625566
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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