Leucinamide → 6-[(4-Fluoro-phenyl)-hydroxy-methyl]-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

HRID 927771노트

반응식

HRID 927771 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:18])[C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[NH2:19][C@@H:20]([CH2:24][CH:25]([CH3:27])[CH3:26])[C:21]([NH2:23])=[O:22]>>[C:21]([C@@H:20]([NH:19][C:15]([C:13]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[OH:18])[N:14]=1)=[O:17])[CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:22])[NH2:23]

참가 물질

3

반응물 2

HCID 69640LeucinamideHCID 710873416-((4-Fluorophenyl)(hydroxy)methyl)picolinic acid

생성물 1

HCID 711057006-[(4-Fluoro-phenyl)-hydroxy-methyl]-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-((4-fluorophenyl)(hydroxy)methyl)picolinic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials. MS (EI): m/e=360.1 [M+H]+.

출처 및 근거

ORD 기록
ord-b07235406c224600adbc0ea62fc18bbf
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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