Ethyl 2-amino-2-ethylbutanoate hydrochloride → Ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-2-ethylbutanoate

HRID 927789

반응식

HRID 927789 반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.Cl.[NH2:22][C:23]([CH2:31][CH3:32])([CH2:29][CH3:30])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([NH:22][C:23]([CH2:29][CH3:30])([CH2:31][CH3:32])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:20])=[N:8][C:9]=2[CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 710876985-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid

생성물 1

HCID 71087869Ethyl 2-(5-cyclopropyl-6-(4-fluorobenzyl)picolinamido)-2-ethylbutanoate

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 155 g) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=413.1 [M+H]+.

출처 및 근거

ORD 기록
ord-85e6f6ea50e84c06aa230a525118ae8b
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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