5-(Dimethylamino)amylamine → (1aRS,7bSR)-5-[2-(5-Dimethylaminopentylamino)benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

HRID 927860노트

반응식

HRID 927860 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:21]([C:22]([OH:24])=[O:23])=[C:20]2[C:15]([CH:16]3[CH2:25][CH:17]3[CH2:18][O:19]2)=[CH:14][CH:13]=1)(=[O:10])=[O:9].[CH3:26][N:27]([CH3:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH2:33]>>[CH3:26][N:27]([CH3:34])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:21]([C:22]([OH:24])=[O:23])=[C:20]2[C:15]([CH:16]3[CH2:25][CH:17]3[CH2:18][O:19]2)=[CH:14][CH:13]=1)(=[O:10])=[O:9]

참가 물질

3

반응물 2

HCID 34659255-(Dimethylamino)amylamineHCID 86713249(1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid2회

생성물 1

HCID 77979720(1aRS,7bSR)-5-[2-(5-Dimethylaminopentylamino)benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

실험 절차

Prepared by proceeding in a similar manner to Example 26, starting from (1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid (Intermediate 67) and 5-dimethylaminopentylamine.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-227b0c1da0254be79aa52074b4743bb5
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290472B2

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