Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3R)-1-Azabicyclo(2.2.2)octan-3-amine → (1aRS,7bSR)-5-{2-[((R)-1-Azabicyclo[2.2.2]oct-3-yl)amino]benzenesulfonyl-amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3R)-1-Azabicyclo(2.2.2)octan-3-amine | HCID 719215 | — |
| 반응물 | (1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid | HCID 86713249 | — |
| 생성물 | (1aRS,7bSR)-5-{2-[((R)-1-Azabicyclo[2.2.2]oct-3-yl)amino]benzenesulfonyl-amino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid | HCID 71006993 | — |
반응 단계
Prepared by proceeding in a similar manner to Example 73, starting from (1aRS,7bSR)-5-(2-fluorobenzenesulfonylamino)-1,1a,2,7b-tetrahydrocyclopropa-[c]chromene-4-carboxylic acid (Intermediate 67) and (R)-1-azabicyclo[2.2.2]oct-3-ylamine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09290472B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-e8960949299747ae853689d8100d4484 |
| 출처 메모 | uspto-grants-2016_03 |