Trifluoroacetic acid → 3-(R)-(3-fluorobenzyl)pyrrolidine
반응식
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][C@@H:13]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1>C(Cl)Cl>[F:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][C@@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1참가 물질
4
실험 절차
Trifluoroacetic acid (10 mL) was added to a solution of tert butyl (R)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate (Intermediate 99, 0.515 g) in DCM (10 mL) and the mixture was stirred for 1 hour at room temperature. The mixture was evaporated to dryness and the residue was partitioned between DCM and saturated aqueous NaHCO3. The organic extract was separated, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give 3-(R)-(3-fluoro-benzyl)pyrrolidine (0.402 g) as an oil.
후처리
- customThe mixture was evaporated to dryness
- customthe residue was partitioned between DCM and saturated aqueous NaHCO3
- extractionThe organic extract
- customwas separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- customThe filtrate was evaporated to dryness
출처 및 근거
- ORD 기록
- ord-9b1b0b3733e54e85933a36e9ecd6bded
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09290472B2
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