Ammonium Hydroxide → 3-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

HRID 928261

반응식

HRID 928261 반응식
C[O:2][C:3]([C:5]1[C:10]([NH:11][C:12](=[O:21])[C:13]2[CH:18]=[C:17]([Br:19])[CH:16]=[CH:15][C:14]=2[F:20])=[N:9][CH:8]=[CH:7][N:6]=1)=O.[NH4+:22].[OH-]>C(O)C>[Br:19][C:17]1[CH:16]=[CH:15][C:14]([F:20])=[C:13]([CH:18]=1)[C:12]([NH:11][C:10]1[C:5]([C:3]([NH2:22])=[O:2])=[N:6][CH:7]=[CH:8][N:9]=1)=[O:21]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 577423823-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic Acid Methyl Ester

생성물 1

HCID 577423843-(5-Bromo-2-fluorobenzoylamino)pyrazine-2-carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3-(5-bromo-2-fluorobenzoylamino)pyrazine-2-carboxylic acid methyl ester 102 (2.6 g, 7.34 mmol) and NH4OH (15 mL) in ethanol (50 mL) was heated at reflux for 10 min. Then, the reaction mixture was cooled at room temperature and the precipitate was filtered off, washed with ethanol and ether to give 2.1 g of the title product 103 as a white powder (LCMS analysis).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 10 min
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol and ether

출처 및 근거

ORD 기록
ord-69d79c10a6a24885b5886e0cebd64be8
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290502B2

연결된 노트

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