Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 928265생성일: 2026년 10월 26일
Triethylamine → 4-[[2-(5-Bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic Acid Methyl Ester
https://huagongshe.com/reaction/928265
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 4-aminopyridine-3-carboxylate | HCID 592353 | — |
| 반응물 | 2-(5-Bromo-2-fluorophenyl)-4-Chloropteridine | HCID 57742381 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 4-[[2-(5-Bromo-2-fluorophenyl)pteridin-4-yl]amino]nicotinic Acid Methyl Ester | HCID 57742379 | 74.6% |
반응 단계
To a solution of 2-(5-bromo-2-fluorophenyl)-4-chloropteridine 106 (200 mg, 0.589 mmol), 4-aminonicotinic acid methyl ester (224 mg, 1.47 mmol) in dichloroethane (5 mL), was added dropwise triethylamine (300 μL, 2.07 mmol). The resulting mixture was heated at 70° C. for 15 min, then quenched with silica and purified by column chromatography (AcOEt/CH2Cl2/triethylamine, 70/19/1). Crystallization from AcOEt/Et2O afforded 200 mg of the title product 107 as yellow prisms (LCMS analysis).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09290502B2 |
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| 출처 데이터셋 | uspto-grants-2016_03 |
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| ORD ID | ord-9114b28750b041699f72acfb20787d81 |
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| 출처 메모 | uspto-grants-2016_03 |
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