Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one | HCID 136109958 | — |
| 생성물 | 2-(5-Bromo-2-pyrrolidin-1-ylphenyl)pteridin-4-one | HCID 136109957 | — |
반응 단계
A solution of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 in pyrrolidine was heated in a microwave cavity (Power=270 W, Temp=110° C.) for 12 min. The pyrrolidine was evaporated, then residue partitioned between NaHCO3 0.5 N and CH2Cl2, dried (Na2SO4) and evaporated. Trituration in Et2O afforded the title product 110 as a yellow powder (LCMS analysis).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09290502B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-bcd291c8f63c4093805a96ab93d1a512 |
| 출처 메모 | uspto-grants-2016_03 |