Acalabrutinib Intermediate → HCID 86720323, 화합물

HRID 928345

반응식

HRID 928345 반응식
[NH2:1][C:2]1[C:3]2[N:4]([C:8]([C@@H:26]3[CH2:30][CH2:29][CH2:28][NH:27]3)=[N:9][C:10]=2[C:11]2[CH:25]=[CH:24][C:14]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[O:16])=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1>C(O)(=O)C#CCC>[NH2:1][C:2]1[C:3]2[N:4]([C:8]([C@@H:26]3[CH2:30][CH2:29][CH2:28][N:27]3[C:15](=[O:16])[C:14]#[C:13][CH2:12][CH3:11])=[N:9][C:10]=2[C:11]2[CH:25]=[CH:24][C:14]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[O:16])=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

3

반응물 1

HCID 71226368Acalabrutinib Intermediate

생성물 1

HCID 86720323HCID 86720323, 화합물수율 24.7%

시약·촉매·용매 1

HCID 3243792-Pentynoic acid용매

실험 절차

This compound was prepared, in an analogous manner as described in Example 2, from the compound described in intermediate 2b and pent-2-ynoic acid, to afford the title compound (7.4 mg, 24.7%). Data: UPLC (C) Rt: 1.73 min; m/z 480.3 (M+H)+.

후처리

  1. customThis compound was prepared, in an analogous manner

출처 및 근거

ORD 기록
ord-0747073207714c25bffff2d57bea7b6b
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290504B2

연결된 노트

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