Styrene Oxide → Ethyl 1-(2-hydroxy-1-phenylethyl)-1H-pyrazole-4-carboxylate

HRID 928381

반응식

HRID 928381 반응식
[NH:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]1.[CH2:11]1[O:19][CH:12]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O.O.O.O.O.O.[N+]([O-])([O-])=O.[Y+3].[N+]([O-])([O-])=O.[N+]([O-])([O-])=O>[OH:19][CH2:11][CH:12]([N:1]1[CH:5]=[C:4]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:3]=[N:2]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 7276Styrene OxideHCID 142179ethyl 1H-pyrazole-4-carboxylate

생성물 1

HCID 58081358Ethyl 1-(2-hydroxy-1-phenylethyl)-1H-pyrazole-4-carboxylate

시약·촉매·용매 1

HCID 166833Yttrium (III) nitrate hexahydrate (1:3:6)촉매

실험 절차

A mixture of ethyl 1H-pyrazole-4-carboxylate (1.5 g, 10.7 mmol), yttrium (III) nitrate hexahydrate (82.0 mg, 0.214 mmol) and styrene oxide (1.21 ml, 10.7 mmol) was stirred at rt for 17 h, before it was adsorbed on celite. Purification by column chromatography (CombiFlash Companion, 12 g SiO2, heptane to EA) afforded the title compound. LCMS RtM=1.72 min, [M+H]+=261.2.

후처리

  1. customPurification by column chromatography (CombiFlash Companion, 12 g SiO2, heptane to EA)

출처 및 근거

ORD 기록
ord-486c5ab2a8c54811b66f349292178b26
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290485B2

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