Toluene → Methyl 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylate
반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:14].[C:15]1(C)C=CC=CC=1>CO>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]([O:13][CH3:15])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH3:14]참가 물질
4
실험 절차
To a suspension of 1,2-Dimethyl-1H-benzo[d]imidazole-5-carboxylic acid (crude, 2.54 g, approx. 9.35 mmol) in MeOH (15.5 ml)/toluene (78 ml) Trimethylsilyldiazomethane (2 M solution in hexane, 7.0 ml, 14 mmol) was added at 0-10° C. The reaction mixture was stirred at it for 1 hour. The reaction mixture was evaporated under reduced pressure. The residue was taken up in DCM, Remaining insoluble solid was filtered off. The filtrate was evaporated again to dryness to afford crude Methyl 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylate
후처리
- additionwas added at 0-10° C
- customThe reaction mixture was evaporated under reduced pressure
- filtrationwas filtered off
- customThe filtrate was evaporated again to dryness
출처 및 근거
- ORD 기록
- ord-e526c639768d4100a852bb5e94a042d8
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09290485B2
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