Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate → ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

HRID 928530

반응식

HRID 928530 반응식
[N:1]([C:4](=[CH:10][C:11]1[S:12][C:13]([Br:16])=[CH:14][CH:15]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[N+]=[N-]>CC1C=CC=CC=1C>[Br:16][C:13]1[S:12][C:11]2[CH:10]=[C:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH:1][C:15]=2[CH:14]=1

참가 물질

3

반응물 1

HCID 73166977Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate

생성물 1

HCID 13164349ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate수율 82%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Acrylate 60 (3.81 g, 12.6 mmol) in o-xylene was refluxed for 20 min. After removing the o-xylene, the crude product was purified by column chromatography (EtOAc/Hexane: 1/10) to give carboxylate 61 (2.83 g, 82%) as a white solid.

후처리

  1. customAfter removing the o-xylene
  2. customthe crude product was purified by column chromatography (EtOAc/Hexane: 1/10)

출처 및 근거

ORD 기록
ord-c3dcae264c9d41bf87b18a0dccf7e3e8
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290512B2

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