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Ethanol → 2-[[2-(5-Isopropylthieno[2,3-d]pyrimidin-4-yl)-2-azabicyclo[2.2.1]heptan-5-yl]oxy]ethanol

HRID 928566
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HRID 928566 반응식
Cl[C:2]1[C:3]2[C:10]([CH:11]([CH3:13])[CH3:12])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH:14]12[CH2:24][CH:17]([CH:18]([O:20][CH2:21][CH2:22][OH:23])[CH2:19]1)[CH2:16][NH:15]2.C(N(CC)CC)C.C(O)C>>[CH:11]([C:10]1[C:3]2[C:2]([N:15]3[CH2:16][CH:17]4[CH2:24][CH:14]3[CH2:19][CH:18]4[O:20][CH2:21][CH2:22][OH:23])=[N:7][CH:6]=[N:5][C:4]=2[S:8][CH:9]=1)([CH3:13])[CH3:12]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 702EthanolHCID 8471TriethylamineHCID 27576264-Chloro-5-isopropyl-thieno[2,3-D]pyrimidineHCID 895794962-(2-Azabicyclo[2.2.1]heptan-5-yloxy)ethanol

생성물 1

HCID 895794632-[[2-(5-Isopropylthieno[2,3-d]pyrimidin-4-yl)-2-azabicyclo[2.2.1]heptan-5-yl]oxy]ethanol

반응 조건

온도
50 °C

실험 절차

4-Chloro-5-isopropyl-thieno[2,3-d]pyrimidine (0.35 g, 1.6 mmol), 2-(2-azabicyclo[2.2.1]heptan-5-yloxy)ethanol (0.39 g, 2.5 mmol), triethylamine (0.50 g, 0.70 mL, 4.9 mmol) and ethanol (3.95 g, 5 mL, 85.6 mmol) were combined and heated to 50° C. overnight. The reaction mixture was concentrated in vacuo. The resulting residue was taken up in DCM, washed with water, dried over Na2SO4 and concentrated in vacuo to afford

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. washwashed with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated in vacuo
  5. customto afford

출처 및 근거

ORD 기록
ord-1459f2b32ba24d53bd28067ae2f9fb3d
출처 데이터셋
uspto-grants-2016_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09290511B2

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