Ethyl Acetate → 5-Bromo-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine

참여 물질

역할	이름	HCID	투입량
반응물	Ethyl Acetate	HCID 8857	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	5-Bromo-4-chlorothieno[2,3-d]pyrimidine	HCID 45480299	—
반응물	4-(2-Pyrrolidin-1-ylethoxymethyl)piperidine	HCID 62338872	—
용매	Water	HCID 962	—
용매	Acetonitrile	HCID 6342	—
생성물	5-Bromo-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine	HCID 89579634	93.4%

반응 조건

온도	110 °C

반응 단계

5-Bromo-4-chlorothieno[2,3-d]pyrimidine (828 mg 3.33 mmol) in dry acetonitrile (13 mL) was treated with 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine (1.057 g, 5.0 mmol,) and potassium carbonate (687 mg, 5.0 mmol) and heated at 110° C. for 30 min in a microwave. The reaction was then poured into ethyl acetate (50 mL) and water (30 mL) and the ethyl acetate layer separated, dried over sodium sulphate and concentrated in vacuum to give 5-bromo-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine (1.322 g, 3.11 mmol, 93%). LCMS RT=2.91 min. M+1=427.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09290511B2
출처 데이터셋	uspto-grants-2016_03
ORD ID	ord-a26ce6502f2e45e6aea926548a44d7cb
출처 메모	uspto-grants-2016_03