3,4-Dehydro-L-proline → (2S)-1-(3-{[4-(4,5-difluoro-1-benzofuran-7-yl)phenoxy]methyl}benzoyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid

HRID 928678노트

반응식

HRID 928678 반응식
[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:27]=[CH:26][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20](O)=[O:21])=[CH:13][CH:12]=2)=[CH:4][C:3]=1[F:28].[NH:29]1[CH2:33][CH:32]=[CH:31][C@H:30]1[C:34]([OH:36])=[O:35]>>[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5]([C:11]2[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20]([N:29]3[CH2:33][CH:32]=[CH:31][C@H:30]3[C:34]([OH:36])=[O:35])=[O:21])=[CH:26][CH:27]=2)=[CH:4][C:3]=1[F:28]

참가 물질

3

반응물 2

HCID 942843,4-Dehydro-L-prolineHCID 903843933-{[4-(4,5-Difluoro-1-benzofuran-7-yl)-phenoxy]methyl}benzoic acid

생성물 1

HCID 89555417(2S)-1-(3-{[4-(4,5-difluoro-1-benzofuran-7-yl)phenoxy]methyl}benzoyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid수율 30%

실험 절차

An operation similar to that in Step 4 of Example 10 was performed using the compound (38.0 mg, 0.100 mmol) of Step 2 of Example 59 in place of 3-{[4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)phenoxy]methyl}benzoic acid, and (2S)-2,5-dihydro-1H-pyrrole-2-carboxylic acid (14.7 mg, 0.130 mmol) in place of L-proline to thus obtain the title compound.

출처 및 근거

ORD 기록
ord-9acc4400dc0d4ab59d78b855897bb807
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290487B2

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