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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 928679생성일: 2026년 10월 25일

L-Thioproline → (4R)-3-(3-{[4-(4,5-difluoro-1-benzofuran-7-yl)phenoxy]methyl}benzoyl)-1,3-thiazolidine-4-carboxylic acid

https://huagongshe.com/reaction/928679

반응식

참여 물질

역할이름HCID투입량
반응물L-ThioprolineHCID 93176—
반응물3-{[4-(4,5-Difluoro-1-benzofuran-7-yl)-phenoxy]methyl}benzoic acidHCID 90384393—
생성물(4R)-3-(3-{[4-(4,5-difluoro-1-benzofuran-7-yl)phenoxy]methyl}benzoyl)-1,3-thiazolidine-4-carboxylic acidHCID 895554472.8%

반응 단계

An operation similar to that in Step 4 of Example 10 was performed using the compound (38.0 mg, 0.100 mmol) of Step 2 of Example 59 in place of 3-{[4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)phenoxy]methyl}benzoic acid, and (4R)-1,3-thiazolidine-4-carboxylic acid (40.0 mg, 0.300 mmol) in place of L-proline to thus obtain the title compound.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09290487B2
출처 데이터셋uspto-grants-2016_03
ORD IDord-9070fffa867244d19d5b2d6540a8eedc
출처 메모uspto-grants-2016_03