5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(4-Methylsulfonylbenzyl)malonic acid

HRID 928727노트

반응식

HRID 928727 반응식
ClC1C=CC(CC2C(=O)OC(C)(C)OC2=O)=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl.[CH3:40][S:41]([C:44]1[CH:60]=[CH:59][C:47]([CH2:48][CH:49]2[C:54](=[O:55])[O:53]C(C)(C)[O:51][C:50]2=[O:58])=[CH:46][CH:45]=1)(=[O:43])=[O:42]>>[CH3:40][S:41]([C:44]1[CH:45]=[CH:46][C:47]([CH2:48][CH:49]([C:50]([OH:58])=[O:51])[C:54]([OH:55])=[O:53])=[CH:59][CH:60]=1)(=[O:42])=[O:43]

참가 물질

4

반응물 3

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3회HCID 867155855-(4-Methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

생성물 1

HCID 867155862-(4-Methylsulfonylbenzyl)malonic acid

실험 절차

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(4-methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 8: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

출처 및 근거

ORD 기록
ord-8a1df965ac81431a80e582799c1c48fe
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290476B2

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