2-(Thiophen-2-ylmethyl)propanedioic acid → HCID 86715588, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1C=C[C:17](Cl)=[CH:16][CH:15]=1)=[C:5]2[Cl:21].[S:22]1C=CC=C1CC(C(O)=O)C(O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[S:22][CH:17]=[CH:16][CH:15]=1)=[C:5]2[Cl:21]

참가 물질

반응물 2

HCID 2365912-(Thiophen-2-ylmethyl)propanedioic acid2회

HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3회

생성물 1

HCID 86715588HCID 86715588, 화합물

실험 절차

The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(thiophen-2-ylmethyl)malonic acid (Intermediate 9: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).

출처 및 근거

ORD 기록: ord-f5b8694512814168a5a802e982ada1ed
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09290476B2

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