3-(Bromomethyl)-2-chloropyridine → 3-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

HRID 929759노트

반응식

HRID 929759 반응식
[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[CH:7]=1)=[O:5])[CH3:2].Br[CH2:19][C:20]1[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=1>>[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:19][C:20]3[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=2)[CH:7]=1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 189310283-(Bromomethyl)-2-chloropyridineHCID 136133842Ethyl 3-(4-hydroxyphenyl)isoxazole-5-carboxylate2회

생성물 1

HCID 902025533-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

실험 절차

3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 1) and 3-bromomethyl-2-chloro-pyridine (which may be prepared as described in Selby, T. P. and Winters, M. P. U.S. Pat. No. 5,739,326 Column 19) were reacted using conditions similar to those described for Preparation of Intermediate 24 to give 3-[4-(2-chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester.

후처리

  1. custom5,739,326 Column 19) were reacted

출처 및 근거

ORD 기록
ord-7d4d68a38fee4b21b104ed3e45d58398
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296711B2

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