5-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid → HCID 89609998, 화합물

HRID 930005노트

반응식

HRID 930005 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2N(C3C=CC=CN=3)N=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[Cl:24][C:25]1[CH:26]=[C:27]([NH:31][NH2:32])[CH:28]=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:31]([C:27]3[CH:28]=[N:29][CH:30]=[C:25]([Cl:24])[CH:26]=3)[N:32]=[C:11]([C:20]([OH:22])=[O:21])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

3

반응물 2

HCID 896025755-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acidHCID 118006407HCID 118006407, 화합물

생성물 1

HCID 89609998HCID 89609998, 화합물

실험 절차

785 mg (2.25 mmol) of the compound of Example 1A is reacted analogously to the synthesis of the compound of Example 20A with 608 mg (3.38 mmol) of 5-chloropyridin-3-yl-hydrazine hydrochloride. After hydrolysis, 270 mg (34% of theory) of the title compound is obtained.

출처 및 근거

ORD 기록
ord-bc6d2b704b654400bdad789c84806736
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296720B2

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