2-Chloro-4-hydrazinylpyridine hydrochloride → 5-(3-Methoxy-5-trifluoromethoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid

HRID 930034노트

반응식

HRID 930034 반응식
[Li].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:15]([O-])=[CH:16][C:17](=O)[C:18]([O:20]CC)=[O:19])[CH:7]=[C:8]([O:10][C:11]([F:14])([F:13])[F:12])[CH:9]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.[Cl:48][C:49]1[CH:54]=[C:53]([NH:55][NH2:56])[CH:52]=[CH:51][N:50]=1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:15]2[N:55]([C:53]3[CH:52]=[CH:51][N:50]=[C:49]([Cl:48])[CH:54]=3)[N:56]=[C:17]([C:18]([OH:20])=[O:19])[CH:16]=2)[CH:7]=[C:8]([O:10][C:11]([F:12])([F:13])[F:14])[CH:9]=1

참가 물질

4

반응물 3

HCID 865938392-Chloro-4-hydrazinylpyridine hydrochlorideHCID 896025755-(3-Chloro-5-fluorophenyl)-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acidHCID 131735136Lithium 1-(3-methoxy-5-trifluoromethoxyphenyl)-4-ethoxy-3,4-dioxobut-1-en-1-olate

생성물 1

HCID 896028375-(3-Methoxy-5-trifluoromethoxyphenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylic acid

실험 절차

500 mg (1.29 mmol) of the compound of Example 10A is reacted analogously to the synthesis of the compound of Example 20A with 256 mg (1.42 mmol) of 2-chloropyridin-4-yl-hydrazine hydrochloride. After hydrolysis, 149 mg (28% of theory) of the title compound is obtained.

출처 및 근거

ORD 기록
ord-df32efde80f3458ab37210f2ee7857d4
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296720B2

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