m-Chloroperbenzoic acid → [5-[3-Chloro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:26]3[CH2:30][CH2:29][S:28][CH2:27]3)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=NC=CC=3)N=C(C(N3CCS(=O)C3)=[O:51])C=2)C=C(F)C=1.ClC1C=CC=C(C(OO)=O)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:26]3[CH2:30][CH2:29][S:28](=[O:51])[CH2:27]3)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:10])([F:11])[F:12])[CH:7]=1참가 물질
4
반응물 3
생성물 1
실험 절차
38 mg (0.08 mmol) of the compound of Example 77 is reacted analogously to the synthesis of the compound of Example 6 with 21 mg (0.08 mmol, 70%) of meta-chloroperbenzoic acid for 4 hours at room temperature. 39 mg (99% of theory) of the title compound is obtained.
출처 및 근거
- ORD 기록
- ord-9528dc51a4c1476fa0f5e3e24c6bf935
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09296720B2
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