참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 5-Chloropyrido[3,4-b]pyrazin-2(1H)-one | HCID 86715742 | — |
| 생성물 | 2,5-Dichloropyrido[3,4-b]pyrazine | HCID 86715743 | 92.4% |
반응 단계
A suspension of 5-chloropyrido[3,4-b]pyrazin-2(1H)-one (0.57 g, 3.14 mmol) in phosphorus oxychloride (10.24 mL, 110 mmol) was stirred at 110° C. for two hours, and then concentrated. The residue was dissolved in DCM, washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered, and concentrated to afford the title compound (580 mg, 2.90 mmol). MS m/z=200 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09296734B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_03 |
|---|
| ORD ID | ord-cadff68031f84708a62f698751562d34 |
|---|
| 출처 메모 | uspto-grants-2016_03 |
|---|
