4-(6-(Trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-one → tert-Butyl 7-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

HRID 930705노트

반응식

HRID 930705 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:22][CH2:21][C:7]=3[N:8]([Si](C(C)C)(C(C)C)C(C)C)[C:9]=2[CH:10]=1.[F:32][C:33]([F:48])([F:47])[C:34]1[N:39]=[N:38][C:37]([C:40]2[CH:45]=[CH:44][NH:43][C:42](=[O:46])[CH:41]=2)=[CH:36][CH:35]=1>>[O:46]=[C:42]1[CH:41]=[C:40]([C:37]2[N:38]=[N:39][C:34]([C:33]([F:48])([F:47])[F:32])=[CH:35][CH:36]=2)[CH:45]=[CH:44][N:43]1[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:24][N:23]([C:25]([O:27][C:28]([CH3:29])([CH3:31])[CH3:30])=[O:26])[CH2:22][CH2:21][C:7]=3[NH:8][C:9]=2[CH:10]=1

참가 물질

3

반응물 2

HCID 579502624-(6-(Trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-oneHCID 57950390tert-Butyl 7-bromo-5-(triisopropylsilyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

생성물 1

HCID 57950449tert-Butyl 7-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate수율 30.7%

실험 절차

tert-Butyl 7-bromo-5-(triisopropylsilyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (260 mg, 0.51 mmol) and 4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-one (123 mg, 0.510 mmol) were reacted according to the procedure of Example 30 (step g) to provide the title compound (80 mg, 30%) as a yellow solid: ESI MS m/z 512 [M+H]+.

출처 및 근거

ORD 기록
ord-caa77cd8e430429eb8c416538de5a958
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296743B2

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