2-(4-Chloro-3-(trifluoromethyl)phenoxy)-5-(hydroxymethyl)benzonitrile → 2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(((1-cyclopropyl-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidin-8-yl)oxy)methyl)benzonitrile
반응식
Cl[C:2]1[CH:14]=[C:6]2[N:7]([CH:11]3[CH2:13][CH2:12]3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:15])[N:3]=1.[Cl:16][C:17]1[CH:33]=[CH:32][C:20]([O:21][C:22]2[CH:29]=[CH:28][C:27]([CH2:30][OH:31])=[CH:26][C:23]=2[C:24]#[N:25])=[CH:19][C:18]=1[C:34]([F:37])([F:36])[F:35]>>[Cl:16][C:17]1[CH:33]=[CH:32][C:20]([O:21][C:22]2[CH:29]=[CH:28][C:27]([CH2:30][O:31][C:2]3[CH:14]=[C:6]4[N:7]([CH:11]5[CH2:13][CH2:12]5)[CH2:8][CH2:9][CH2:10][N:5]4[C:4](=[O:15])[N:3]=3)=[CH:26][C:23]=2[C:24]#[N:25])=[CH:19][C:18]=1[C:34]([F:35])([F:36])[F:37]참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and 2-(4-chloro-3-(trifluoromethyl) phenoxy)-5-(hydroxymethyl)benzonitrile.