Ethanesulfonyl chloride → HCID 71617336, 화합물

반응식

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][C:20]2[CH:25]=[CH:24]C=C[CH:21]=2)=[C:6]([C:8]2[C:9]3[CH:18]=[CH:17][NH:16][C:10]=3[C:11](=[O:15])[N:12]([CH3:14])[CH:13]=2)[CH:7]=1.[CH2:26]([S:28](Cl)(=[O:30])=[O:29])[CH3:27].CS(Cl)(=O)=[O:34]>>[CH3:14][N:12]1[CH:13]=[C:8]([C:6]2[CH:7]=[C:2]([NH:1][S:28]([CH2:26][CH3:27])(=[O:30])=[O:29])[CH:3]=[CH:4][C:5]=2[O:19][CH:20]2[CH2:25][CH2:24][O:34][CH2:21]2)[C:9]2[CH:18]=[CH:17][NH:16][C:10]=2[C:11]1=[O:15]

참가 물질

반응물 3

HCID 11667Ethanesulfonyl chloride

HCID 31297Methanesulfonyl chloride

HCID 716162994-(5-amino-2-phenoxyphenyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

생성물 1

HCID 71617336HCID 71617336, 화합물

실험 절차

Example 66 was prepared according to the procedure used in method A of Example 4, substituting the product of Example 31b for the product of Example 3, and ethanesulfonyl chloride for methanesulfonyl chloride, respectively, to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 1.22 (t, J=7.3 Hz, 3H), 1.93-1.80 (m, 1H), 2.20-2.04 (m, 1H), 3.02 (q, J=7.3 Hz, 2H), 3.55 (s, 3H), 3.65 (m, 3H), 3.82 (dd, J=10.0, 4.5 Hz, 1H), 5.00-4.91 (m, 1H), 6.16 (t, J=2.3 Hz, 1H), 7.06 (d, J=8.8 Hz, 1H), 7.16 (dd, J=8.7, 2.7 Hz, 1H), 7.24 (s, 1H), 7.31-7.25 (m, 3H), 9.53 (s, 1H), 12.01 (bs, 1H), MS (ESI+) m/z 418.1 (M+H)+.