5-Bromo-1,2,3-trimethoxybenzene → HCID 178418846, 화합물

HRID 9310

반응식

HRID 9310 반응식
C([Li:5])CCC.[CH3:6][O:7][C:8]1[CH:9]=[C:10](Br)[CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15]>CCOCC>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([Li:5])[CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15]

참가 물질

4

반응물 2

HCID 758855-Bromo-1,2,3-trimethoxybenzeneHCID 178418339Butyllithium

생성물 1

HCID 178418846HCID 178418846, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a stirred solution of n-butyllithium (3.7 mL, 1.6 M in hexane solution,6.0 mol) in dry ether (40 mL), a solution of 3,4,5-trimethoxyphenylbromide (0.74 g, 3.0 mol) in ether (20 mL) was added under dry nitrogen at −78° C. The solution was stirred for 1 h in order to form 3,4,5-trimethoxyphenyllithum (“TPL”). Substituted tetralone reagent (3.0 mol) was added at −20° C., and the stirring was continued for 2 h (−20° C.-RT). The mixture was partitioned between CH2Cl2 and water, the organic layer was dried over anhydrous sodium sulfate, and, after filtration, the organic layer was concentrated in vacuo to provide a tetrahydronaphthalen-1-ol as a yellow oil. Each compound was purified by column chromatography.

출처 및 근거

ORD 기록
ord-44b54a3e212a410d8860722b1d5535c3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091240B2

연결된 노트

불러오는 중…