Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 931040

반응식

HRID 931040 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[Br:10]Br>C(O)(=O)C>[NH2:1][C:2]1[C:9]([Br:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

생성물 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 6-aminonicotinonitrile (5.0 g) in acetic acid (50 mL) was added bromine (4.3 mL) under ice-cooling. The reaction mixture was stirred at room temperature for 3 days, and the precipitate was collected by filtration. The obtained solid was suspended in ethyl acetate and IPE, and collected by filtration to give the title compound (8.2 g).

후처리

  1. temperaturecooling
  2. filtrationthe precipitate was collected by filtration
  3. filtrationIPE, and collected by filtration

출처 및 근거

ORD 기록
ord-c37ee5a966f84b3ba9f10a38389ad20d
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296746B2

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