Trifluoroacetic acid → 1-(4-Methyl-1H-pyrazol-1-YL)cyclopropane-1-carboxylic acid

HRID 931063노트

반응식

HRID 931063 반응식
[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]([O:12]C(C)(C)C)=[O:11])[CH2:9][CH2:8]2)[CH:6]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]([OH:12])=[O:11])[CH2:8][CH2:9]2)[CH:6]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acid3회HCID 117966666tert-butyl 1-(4-methyl-1H-pyrazol-1-yl)cyclopropanecarboxylate

생성물 1

HCID 898536841-(4-Methyl-1H-pyrazol-1-YL)cyclopropane-1-carboxylic acid수율 220.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a 100 mL pear shaped flask containing tert-butyl 1-(4-methyl-1H-pyrazol-1-yl)cyclopropanecarboxylate (218 mg, 0.981 mmol) were added dichloromethane (5 mL) and trifluoroacetic acid (0.2 mL, 3 mmol). The clear solution was stirred at room temperature for 30 minutes after which another 0.3 mL of trifluoroacetic acid were added. The mixture was stirred at room temperature for 45 minutes and another 0.3 mL of trifluoroacetic acid were added. The mixture was stirred at room temperature for 18 h. The solvent and excess of trifluoroacetic acid were removed under reduced pressure to afford the title compound (360 mg). The material was used without further purification. 1H NMR (400 MHz, CDCl3) δ 1.78 (m, 2H), 2.02 (m, 2H), 2.17 (s, 3H), 7.54 (s, 1H), 7.74 (s, 1H).

후처리

  1. additionwere added
  2. stirringThe mixture was stirred at room temperature for 18 h
  3. customThe solvent and excess of trifluoroacetic acid were removed under reduced pressure

출처 및 근거

ORD 기록
ord-ea61894d7ae84311a5faf5d8d69304b2
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

반응 노트

불러오는 중…