p-Toluenesulfonic acid → 6-(3-Hydroxyoxetan-3-yl)picolinaldehyde

HRID 931088노트

반응식

HRID 931088 반응식
[O:1]1CCO[CH:2]1[C:6]1[N:11]=[C:10]([C:12]2([OH:16])[CH2:15][O:14][CH2:13]2)[CH:9]=[CH:8][CH:7]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[OH:16][C:12]1([C:10]2[N:11]=[C:6]([CH:2]=[O:1])[CH:7]=[CH:8][CH:9]=2)[CH2:15][O:14][CH2:13]1

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 89853573HCID 89853573, 화합물

생성물 1

HCID 898538636-(3-Hydroxyoxetan-3-yl)picolinaldehyde

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 3-(6-(1,3-dioxolan-2-yl)pyridin-2-yl)oxetan-3-ol (67 mf, 0.30 mmol) and p-toluenesulphonic acid (14.8 mg, 0.26 mmol) in acetone (3.00 mL) was heated to 50° C. and stirred for 18 h. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure to afford the title compound. The material was used without further purification. MS (ES+) (M+H) 180.0; LCMS retention time: 1.57 minutes (Method L).

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-6f07fe5e01cd4d50a70cd445a0a38a1f
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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