Sodium ethoxide → Ethyl 6-cyclopropylpyrazine-2-carbimidate

HRID 931107노트

반응식

HRID 931107 반응식
[O-:1][CH2:2][CH3:3].[Na+].[CH:5]1([C:8]2[N:13]=[C:12]([C:14]#[N:15])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1>C(O)C>[CH:5]1([C:8]2[N:13]=[C:12]([C:14](=[NH:15])[O:1][CH2:2][CH3:3])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 898540196-Cyclopropylpyrazine-2-carbonitrile

생성물 1

HCID 89853280Ethyl 6-cyclopropylpyrazine-2-carbimidate수율 126.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium ethoxide (140 mg, 2.06 mmol) was added to a solution of 6-cyclopropylpyrazine-2-carbonitrile (150 mg, 1.03 mmol) in ethanol (6 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between water and ethyl acetate. The organics were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (250 mg). MS (ES+) (M+H) 192.1012

후처리

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was partitioned between water and ethyl acetate
  3. dry with materialThe organics were dried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ba63df32974e4e66958fbfae49e03872
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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