Sodium ethoxide → HCID 89853752, 화합물

HRID 931138

반응식

HRID 931138 반응식
[CH:1]1([C:4]2[CH:5]=[N:6][CH:7]=[C:8]([CH:11]=2)[C:9]#[N:10])[CH2:3][CH2:2]1.[O-:12][CH2:13][CH3:14].[Na+]>C(O)C>[CH:1]1([C:4]2[CH:5]=[N:6][CH:7]=[C:8]([CH:11]=2)[C:9](=[NH:10])[O:12][CH2:13][CH3:14])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 574196235-Cyclopropylnicotinonitrile

생성물 1

HCID 89853752HCID 89853752, 화합물수율 76.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-cyclopropylnicotinonitrile (0.45 g, 3.1 mmol) in ethanol was added sodium ethoxide (0.212 g, 3.1 mmol). The reaction mixture was stirred at room temperature for 12 h. The solvent was removed under reduced pressure, and the residue was partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure to afford the title compound (0.45 g) which was used without further purification. MS (ES+APCI) (M+H) 191.2; LCMS retention time 1.149 min (Method L1).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was partitioned between water and ethyl acetate
  3. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-03f382616c464bf09188db30f5a8de75
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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