Sodium ethoxide → ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

HRID 931148노트

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HRID 931148 반응식
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]#[N:11])[CH2:9][CH2:8]2)[CH:6]=1.[O-:12][CH2:13][CH3:14].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10](=[NH:11])[O:12][CH2:13][CH3:14])[CH2:8][CH2:9]2)[CH:6]=1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 898536581-(4-Chloropyrazol-1-yl)cyclopropane-1-carbonitrile

생성물 1

HCID 117966385ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To a solution of 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbonitrile (17.3 g, 103 mmol) in ethanol (50 mL) was added sodium ethoxide (prepared from 3.2 g, 139 mmol of sodium metal dissolved in 150 mL of ethanol). The reaction mixture was stirred at 70° C. for 2 h to afford ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate which was used for the next step without further purification. An aliquot of the solution was concentrated for analysis: 1H NMR (400 MHz, CDCl3): δ 1.25 (t, 3H), 1.46 (q, 2H), 1.73 (q, 2H), 4.15 (q, 2H), 7.51 (s, 1H), 7.52 (s, 1H).

출처 및 근거

ORD 기록
ord-791bc05e48f644d49b4874cd539ae6aa
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296745B2

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