5-Bromo-7-chloro-2-methylquinolin-6-ol → 5-Bromo-2,7-dimethylquinolin-6-ol

반응식

[Br:1][C:2]1[C:11]([OH:12])=[C:10](Cl)[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:14])=[N:7]2.[CH3:15]C1C=CC2C(=CC(C)=C(O)C=2)N=1>>[Br:1][C:2]1[C:11]([OH:12])=[C:10]([CH3:15])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:14])=[N:7]2

참가 물질

반응물 2

HCID 666313995-Bromo-7-chloro-2-methylquinolin-6-ol

HCID 666314242,7-Dimethylquinolin-6-ol

생성물 1

HCID 666314165-Bromo-2,7-dimethylquinolin-6-ol

실험 절차

Compound 2C was prepared following the procedure used to prepare compound 1D of Example 1, except that 2,7-dimethylquinolin-6-ol (2B) was used instead of compound 1C. LCMS-ESI+ (m/z): 252.2, 254.2 (M+H)+.

출처 및 근거

ORD 기록: ord-627ad1fbc556470fa3d5d3e6e4e12fdd
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09296758B2

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