7-Chloro-5-(4-chlorophenyl)-2-methylquinolin-6-ol → 5-(4-Chlorophenyl)-2,7-dimethylquinolin-6-ol

반응식

Cl[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[OH:20].Br[C:22]1C(O)=C(C)C=C2C=1C=CC(C)=N2>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:4]2[C:3]([OH:20])=[C:2]([CH3:22])[CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([CH3:12])=[N:9]3)=[CH:14][CH:15]=1

참가 물질

반응물 2

HCID 666313897-Chloro-5-(4-chlorophenyl)-2-methylquinolin-6-ol

HCID 666314165-Bromo-2,7-dimethylquinolin-6-ol

생성물 1

HCID 666320955-(4-Chlorophenyl)-2,7-dimethylquinolin-6-ol

실험 절차

Compound 2D was prepared following the procedure used to prepare compound 1E of Example 1, except that 5-bromo-2,7-dimethylquinolin-6-ol (2C) was used instead of compound 1D. LCMS-ESI+ (m/z): 284.2, 286.2 (M+H)+.

출처 및 근거

ORD 기록: ord-a7d54aaefc5f44909bc56ccc93ffac6d
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09296758B2

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