8-(4-Chlorophenyl)-7-methoxy-6-methylquinoline → 8-(4-Chlorophenyl)-6-methylquinolin-7-ol

반응식

ClC1C=C2C(C=CC(C)=N2)=CC=1O.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[C:22]([O:32]C)=[C:23]([CH3:31])[CH:24]=[C:25]3[C:30]=2[N:29]=[CH:28][CH:27]=[CH:26]3)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[C:22]([OH:32])=[C:23]([CH3:31])[CH:24]=[C:25]3[C:30]=2[N:29]=[CH:28][CH:27]=[CH:26]3)=[CH:19][CH:20]=1

참가 물질

반응물 2

HCID 666310868-(4-Chlorophenyl)-7-methoxy-6-methylquinoline

HCID 666314067-Chloro-2-methylquinolin-6-ol

생성물 1

HCID 1363368158-(4-Chlorophenyl)-6-methylquinolin-7-ol

실험 절차

Compound 4C was prepared following the procedure used to prepare compound 1C of Example 1, except that 8-(4-chlorophenyl)-7-methoxy-6-methylquinoline (4B) was used instead of compound 1B. LCMS-ESI+ (m/z): 270.2, 272.2 (M+H)+.

출처 및 근거

ORD 기록: ord-530ec4abf0b443f3bd7bf0e519310f01
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09296758B2

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