5-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-ol → 5-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-yl trifluoromethanesulfonate

HRID 931737노트

반응식

HRID 931737 반응식
[F:1][C:2]([F:27])([F:26])[S:3](OC1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)(=[O:5])=[O:4].[Br:28][C:29]1[C:38]([OH:39])=[C:37]([CH3:40])[CH:36]=[C:35]2[C:30]=1[CH:31]=[CH:32][C:33]([C:41]([F:44])([F:43])[F:42])=[N:34]2>>[F:1][C:2]([F:27])([F:26])[S:3]([O:39][C:38]1[C:29]([Br:28])=[C:30]2[C:35](=[CH:36][C:37]=1[CH3:40])[N:34]=[C:33]([C:41]([F:42])([F:43])[F:44])[CH:32]=[CH:31]2)(=[O:5])=[O:4]

참가 물질

3

반응물 2

HCID 666316125-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-olHCID 866919727-Chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl trifluoromethanesulfonate

생성물 1

HCID 866919785-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-yl trifluoromethanesulfonate

실험 절차

Compound 7C was prepared following the procedure used to prepare compound 1F of Example 1 except that 5-bromo-7-methyl-2-(trifluoromethyl)quinolin-6-ol (7B) was used instead of compound 1E. LCMS-ESI+ (m/z): 437.8, 439.8 (M+H)+.

출처 및 근거

ORD 기록
ord-6c24469a56ea4520ae5e1644d8f98161
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296758B2

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