Acetaldehyde → HCID 68326248, 화합물

HRID 931845노트

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HRID 931845 반응식
[F:1][C:2]1[C:7]([Br:8])=[C:6](Br)[CH:5]=[C:4]([Br:10])[CH:3]=1.[CH:11](=[O:13])[CH3:12]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([Br:10])[CH:5]=[C:6]([CH:11]([OH:13])[CH3:12])[C:7]=1[Br:8]

참가 물질

4

반응물 2

HCID 177AcetaldehydeHCID 27249131,2,5-Tribromo-3-fluorobenzene

생성물 1

HCID 68326248HCID 68326248, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
-70 °C

실험 절차

120 g (0.36 mol) of 6-fluoro-1,2,4-tribromobenzene in 120 ml of tetrahydrofuran are added dropwise to 290 ml (0.38 mol, 1.3 M solution in tetrahydrofuran) of isopropylmagnesium chloride/lithium chloride complex cooled to −70° C., and the mixture is stirred at −50° C. for 2 h. The mixture is subsequently cooled to −70° C., before 17.6 g (0.4 mol) of acetaldehyde in 40 ml of tetrahydrofuran are added dropwise. The batch is slowly warmed to −20° C. and then quenched by the addition of saturated ammonium chloride solution.

후처리

  1. additionare added dropwise
  2. temperatureThe batch is slowly warmed to −20° C.
  3. customquenched by the addition of saturated ammonium chloride solution

출처 및 근거

ORD 기록
ord-55232c93ccfd4823b057497427c57ff6
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296948B2

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