Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → 3-Acetyl-isoquinoline oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 1-(Isoquinolin-3-yl)ethan-1-one | HCID 11275275 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Acetyl-isoquinoline oxime | HCID 136395991 | 89% |
반응 단계
A solution of 3-acetyl-isoquinoline (0.65 g), hydroxylamine (0.29 g) and sodium acetate (0.47 g) in a mixture of methanol (20 ml) and water (3 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water and extracted with ethyl acetate. The combined extracts were dried, concentrated and triturated with hexane to give 3-acetyl-isoquinoline oxime (0.63, 89% yield) as a white crystalline solid m.p. 135°-142° C.; 1H NMR: 2.50(3H,s); 7.61(1H,t); 7.70(1H,t); 7.87(1H,d); 7.99(1H,d); 8.11(1H,s); 9.28(1H,s) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723473 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-6886621a94c642309e84fee2699ce813 |
| 출처 메모 | uspto-grants-1998_03 |