Hexane → HCID 178419043, 화합물

HRID 9334

반응식

HRID 9334 반응식
[CH2:1]([O:8][N:9]=[C:10]1[C:18]2([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15](Br)[CH:16]=2)[NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25][O:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[CH:31][CH:32]=1.CCCCCC>C(OCC)(=O)C>[CH2:1]([O:8][N:9]=[C:10]1[C:18]2([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:31]3[CH:30]=[CH:29][CH:28]=[C:27]([O:26][CH3:25])[CH:32]=3)[CH:16]=2)[NH:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 2734370(3-Methoxyphenyl)boronic acidHCID 178419047HCID 178419047, 화합물

생성물 1

HCID 178419043HCID 178419043, 화합물수율 75%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Prepared from 5′-bromospiro{cyclohexane-1,3′-[3H]indol}-2′(1′H)-one 2′(O-benzyloxime) (1.0 g, 2.6 mmol) and 3-methoxyphenyl boronic acid (0.79 g, 5.2 mmol) according to Example 45 procedure A. The product was purified by flash silica gel chromatography; (eluant: 10:0.5 hexane:ethyl acetate) to give the desired product (0.80 g, 1.9 mmol, 75%) as a viscous oil. 1H NMR (500 MHz, DMSO-d6) δ 1.43–1.78 (8H, m), 1.95–2.00 (2H, q), 3.80 (3H, s), 5.00 (2H, s), 6.82–6.86 (2H, m), 7.10–7.16 (2H, m), 7.28–7.53 (10H, m), 9.57 (1H, s); MS (ESI(−ve)) m/z 411 (M−H)−.

후처리

  1. customThe product was purified by flash silica gel chromatography

출처 및 근거

ORD 기록
ord-505d378986564b289b6586ca9291e8b6
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091234B2

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