5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{1-[4-(3,4-Difluoro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

반응식

[F:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11](-[n:19]3[cH:20][n:21][c:22]([I:24])[cH:23]3)[n:12][c:13]([C:15]([F:16])([F:17])[F:18])[cH:14]2)[cH:5][cH:6][c:7]1[F:8].[NH2:25][c:26]1[n:27][cH:28][c:29]([B:32]2[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]2)[cH:30][cH:31]1>>[F:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11](-[n:19]3[cH:20][n:21][c:22](-[c:29]4[cH:28][n:27][c:26]([NH2:25])[cH:31][cH:30]4)[cH:23]3)[n:12][c:13]([C:15]([F:16])([F:17])[F:18])[cH:14]2)[cH:5][cH:6][c:7]1[F:8]

참가 물질

반응물 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HCID 574687924-(3,4-Difluoro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine

생성물 1

HCID 602094765-{1-[4-(3,4-Difluoro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

출처 및 근거

ORD 기록: ord-4e4567ff98304ac6ab86363740fd23ac
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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