5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{3-[6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyridin-2-ylamine

반응식

[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([CH:24]3[CH2:25][CH2:26]3)[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1.[NH2:27][c:28]1[n:29][cH:30][c:31]([B:34]2[O:35][C:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[O:42]2)[cH:32][cH:33]1>>[c:2]1(-[c:31]2[cH:30][n:29][c:28]([NH2:27])[cH:33][cH:32]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([CH:24]3[CH2:25][CH2:26]3)[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1

참가 물질

반응물 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HCID 574687462-(3-Bromo-phenyl)-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine

생성물 1

HCID 602093745-{3-[6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyridin-2-ylamine

출처 및 근거

ORD 기록: ord-b3822ff283d6437488f57e07fc6d266b
출처 데이터셋: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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