Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-tert-Butylphenylboronic acid → 8-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-tert-Butylphenylboronic acid | HCID 2734320 | — |
| 반응물 | 8-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 11174597 | — |
| 생성물 | 8-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 21984205 | — |
반응 단계
8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and 4-tert-butylbenzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by chromatography on silica gel (7% methanol in CH2Cl2) afforded 8-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. >250° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091214B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6fe7ec3643804528b4183e666763a9a5 |
| 출처 메모 | uspto-grants-2006_08 |