4-tert-Butylphenylboronic acid → 8-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

HRID 9367

반응식

HRID 9367 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7]([NH2:12])[C:6]3[N:13]=[CH:14][N:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:5]=3[C:4]=2[CH:3]=1.[C:20]([C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([C:24]1[CH:29]=[CH:28][C:27]([C:2]2[CH:11]=[CH:10][C:9]3[N:8]=[C:7]([NH2:12])[C:6]4[N:13]=[CH:14][N:15]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:5]=4[C:4]=3[CH:3]=2)=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]

참가 물질

3

반응물 2

HCID 27343204-tert-Butylphenylboronic acidHCID 111745978-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

생성물 1

HCID 219842058-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

실험 절차

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and 4-tert-butylbenzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by chromatography on silica gel (7% methanol in CH2Cl2) afforded 8-(4-tert-butylphenyl)-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. >250° C.

후처리

  1. customRecrystallization from isopropanol

출처 및 근거

ORD 기록
ord-6fe7ec3643804528b4183e666763a9a5
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091214B2

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