Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl vinyl ether → 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl vinyl ether | HCID 8023 | — |
| 반응물 | 1,2-Dibromo-1-chloro-1,2,2-trifluoroethane | HCID 9634 | — |
| 반응물 | 4-Bromo-3-chloro-3,4,4-trifluorobutanal | HCID 21836480 | — |
| 반응물 | Sodium chlorite hydrogen peroxide | HCID 86632281 | — |
| 반응물 | Sodium hydrosulfite sodium bicarbonate | HCID 86749472 | — |
| 생성물 | 4-Bromo-3-chloro-3,4,4-trifluorobutanoic acid | HCID 10912127 | — |
반응 단계
A one pot reaction of 1-chloro-1,2-dibromotrifluoroethane (VI) with ethyl vinyl ether in the presence of sodium hydrosulfite/sodium bicarbonate followed by oxidation of the intermediate, 4-bromo-3-chloro-3,4,4-trifluorobutanal (VII), without isolaton, with sodium chlorite/hydrogen peroxide to give 4-bromo-3-chloro-3,4,4-trifiuorobutanoic acid (VIII) in overall unexpected yields;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723470 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-3730779ac7234e61924027d44b783970 |
| 출처 메모 | uspto-grants-1998_03 |