Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethoxyacetyl chloride → N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethoxyacetyl chloride | HCID 84189 | — |
| 반응물 | 1-(3-Amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol | HCID 21984457 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide | HCID 21984424 | — |
반응 단계
A solution of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol (158.19 g, 0.510 mol) in dichloromethane (1.2 L) was cooled to 0° C. Ethoxyacetyl chloride (62.50 g, 0.510 mol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration to provide N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091214B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-408b6bd98e6c455a89225c1e8c5e9238 |
| 출처 메모 | uspto-grants-2006_08 |