Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromoaniline → 1-[3-(6-Bromo3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | 1-(3-Aminopropyl)-2-pyrrolidinone | HCID 82111 | — |
| 반응물 | 6-Bromo-4-chloro-3-nitroquinoline | HCID 21984128 | — |
| 생성물 | 1-[3-(6-Bromo3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one | HCID 21984201 | 87.8% |
반응 단계
6-Bromo-4-chloro-3-nitroquinoline (50.62 g, 177.8 mmol), prepared from 4-bromoaniline according to the methods described in Parts A–D of Example 1, was treated with 1-(3-aminopropyl)pyrrolidin-2-one (27.5 mL, 196 mmol) according to the method described in Part E of Example 1 to provide 61.41 g of 1-[3-(6-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091214B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-9bc5d76282ce46f99fc9bea711c2f243 |
| 출처 메모 | uspto-grants-2006_08 |